At Harley Street Clinic Surrey, every polynucleotide treatment begins with a consultation at our CQC-registered clinic in Reigate. Your practitioner will assess your skin, discuss the concerns you would like to address and recommend the most appropriate treatment for your skin concerns.
From £350
30–45 Mins
Minimal Downtime
Topical Numbing Cream
2 – 4 Weeks After Final Session
Polynucleotides are purified chains of nucleotides, which are naturally occurring components of DNA. When used as an injectable skin treatment, they are placed at carefully selected points within the skin to support its natural biological processes.
The treatment is primarily used to improve skin quality. It does not aim to reshape facial features or replace lost volume in the same way as a conventional dermal filler. This can make polynucleotides suitable for patients seeking gradual improvement in their skin condition and appearance without significantly altering their facial proportions.
The precise formulation and source of polynucleotides can vary between products. During your consultation, your practitioner will explain which product is recommended, what it contains and how it addresses your individual skin concerns.
Polynucleotide skin rejuvenation targets several common skin concerns, including fine lines, reduced elasticity, uneven texture, dryness and skin that appears tired or crepey.
The treatment is generally selected to support the overall quality of the skin rather than to alter facial shape. It is an option for patients seeking subtle, gradual improvements, subject to an individual assessment.
The face can be treated to address concerns such as fine lines, dryness, uneven texture and a general reduction in skin elasticity.
The under-eye area is a common treatment area because the skin is naturally thin and may develop fine lines or a crepey appearance. Careful assessment is particularly important around the eyes because under-eye concerns vary considerably between patients.
Treatment areas also include the neck and décolletage, subject to assessment of skin texture, hydration and elasticity.
Other areas can only be recommended following an assessment of the skin and confirmation that the selected product is suitable for that use.
Fine lines around the under-eye area
Changes in texture, hydration or elasticity along the neck and décolletage area
Support skin that looks dull, dry or crepey
Other areas showing reduced skin quality or elasticity
Different treatments address different aspects of skin ageing and facial structure. Polynucleotides primarily support skin quality, while dermal fillers, PRP and microneedling have distinct purposes. The most appropriate option depends on your concerns, medical history, skin condition and desired outcome.
| Polynucleotides | Dermal fillers | PRP skin rejuvenation | SkinPen medical microneedling |
|---|---|---|---|
| Support skin quality, hydration and elasticity | Restore volume and support facial contours | Support skin rejuvenation using components obtained from the patient’s own blood | Improve texture through controlled skin stimulation |
| Addresses fine lines, crepey skin, reduced hydration and delicate under-eye skin | Addresses volume loss, facial hollows, reduced definition and changes in facial proportions | Addresses changes in skin texture, tone and overall skin quality | Addresses uneven texture, enlarged pores and certain types of scarring |
| A polynucleotide product is injected into selected areas to support biological processes associated with skin maintenance | A gel is injected beneath the skin to add volume or provide structural support | A blood sample is processed to concentrate platelets before the prepared plasma is introduced into the treatment area | Fine sterile needles create controlled microchannels within the skin |
| Focuses on skin quality within a wider treatment plan, alongside separately assessed treatments for volume, texture or scarring | Fillers can address volume and contour while polynucleotides focus on the condition of the overlying skin. Where both treatments are appropriate, a combined plan addresses skin quality alongside volume and contour | PRP and polynucleotides use different materials but may have overlapping skin quality aims. A practitioner may recommend one treatment or plan them at different stages according to the patient’s needs | Microneedling targets surface texture or selected scarring while polynucleotides support hydration and elasticity. When suitable, the treatments may be scheduled separately as part of a progressive skin plan |
During the consultation, your practitioner will ask about your medical history, medication, allergies and previous treatments. The proposed area will be examined, and your goals will be discussed.
The treatment area is cleansed before the injections are administered. A topical anaesthetic may be used where appropriate to help manage discomfort.
Small amounts of the polynucleotide product are then injected into selected points using a fine needle or another suitable injection method. The approach will depend on the product, treatment area and your individual plan.
Small raised areas may be visible at the injection points immediately after treatment. Redness, swelling, tenderness or bruising can also occur.
You will receive aftercare guidance explaining how to look after the area, which activities or products to avoid temporarily and how to contact the clinic if you have concerns.
Harley Street Clinic Surrey is a CQC-registered aesthetic and cosmetic clinic based in Reigate. Treatment takes place in a clinical environment with patient safety, informed decision-making and appropriate aftercare at the centre of the process.
The clinic takes a consultation-led approach, with treatment recommendations based on the patient’s medical history, skin concerns, suitability and expectations.
All treatments are performed by fully qualified and experienced medical practitioners.
Our clinic is regulated by the Care Quality Commission.
We will follow up with you and take care of any questions you have before or after treatment.
Our doctors are on the General Medical Council's specialist register.
We only use MHRA-approved, market-leading products for all our treatments.
Harley Street Clinic Surrey is located in central Reigate, welcoming patients from across Surrey, Sussex, South London and the wider South East.
The clinic is conveniently positioned for patients travelling from areas including Redhill, Epsom, Banstead, Sutton, Croydon, Oxted, Cobham, Leatherhead, Dorking, Guildford, Woking, Crawley, East Grinstead, Horsham, Tunbridge Wells and Sevenoaks.
Use the map below to find the clinic and plan your journey.
A course of treatments is commonly recommended, but the number of sessions depends on the product, treatment area, skin condition and desired outcome.
Your practitioner will recommend an appropriate course after assessing your skin. Your practitioner will advise whether maintenance sessions are appropriate for you.
You may feel brief pinching, stinging or pressure during the injections. A topical anaesthetic may be applied where appropriate to help manage discomfort.
Tenderness can continue for a short period after treatment. Sensitivity varies between patients and treatment areas.
Some polynucleotide products are derived from purified fish DNA sources; source and composition vary by product.
The cost depends on the product, treatment area, number of sessions and amount of product required.
Harley Street Clinic Surrey will provide current pricing and a personalised quotation following consultation.
Polynucleotide treatment is not suitable for everyone. Treatment should be postponed during pregnancy or breastfeeding, where there is an active infection, inflammation or skin condition affecting the treatment area, or where the patient is unwell. Relevant allergies, medical conditions, autoimmune conditions, bleeding disorders and certain medications may also affect suitability. The practitioner will review the patient’s medical history, medications and allergies before treatment and will assess suitability in accordance with the specific polynucleotide product being used.
Redness, swelling, bruising, tenderness and small raised areas can occur following treatment. Swelling and raised areas usually settle progressively but duration varies, particularly under the eyes. These effects may be more noticeable in delicate areas such as beneath the eyes.
